David Deutsch has plotted out a course toward understanding ultimate reality. His map includes four courses in fact. Here they are:
He is endeavoring to move toward a new way of looking at knowing and explaining.
Here is a brief introduction to Constructor Theory of Information.
And here is Dr Chiara Marletto discussing this same subject in an interview.
Beautiful, smart, and driven. But I digress.
Get out there and get thinking!
9 July: Found this clip which is relevant here.